David was a Principal Investigator at the Translational Research Unit, Papworth Hospital NHS Foundation Trust, Cambridgeshire from 2002 until 2006, having completed his PhD at Cambridge University in 1997 and then worked as a Post-doctoral Research Associate in the Department of Medicine, Cambridge University until 2002.

David has a strong background in assay development and medical diagnostics, and worked on the application of metabolic profiling to human diseases (including heart disease and neurodegenerative disorders), with particular focus on multivariate modelling and other statistical approaches to the analysis of highly multivariate datasets. Between 2006 and 2008, David was Vice-president Research & Development for Pronostics. He was CEO of Total Scientific, a company that provided specialist contract research to small biotechs until its acquisition by RxCelerate in 2018.  David joined Methuselah Health at its inception as Chief Technology Officer in November 2014.